In this case, you can go to its Playback settings and change the autoplay feature. If the PowerPoint video is not playing automatically, then chances are that you could have set some other playback option for it. If you want to play MP4 videos in PowerPoint 2010, you will need Windows 8 or 10 and you will also need to install QuickTime. The best video format to embed in PowerPoint 2010 is WMV or MPEG. What is the best video format for PowerPoint 2010? But all four versions can embed videos directly into slides, so don’t worry if you don’t have the newest make. PowerPoint 2013, 2016, and 2019 are all compatible with most video formats, especially MP4, while WMV is recommended for PowerPoint 2010.